SOT Annual Meeting and ToxExpo Virtual Event 2021

Thank you for visiting us at the SOT Annual Meeting and ToxExpo Virtual Event 2021. The following presentations and events have been contributed and are available for download below.

Please note that registered attendees of the Virtual 2021 SOT Annual Meeting and ToxExpo have access to all presentations at the SOT 2021 event platform until May 31, 2021.

Poster Presentations

• Representations of liver toxicity knowledge by chemotypes based on ontology approach to support biological & chemical grouping in chemical safety assessment
  J. Firman¹, T. Magdziarz², B. Bienfait², M. Cronin¹, D. Ebbrell¹, S. Enoch¹, B. Hobocienski³, J. Madden¹, A. Mostrag-Szlichtyng³, J. Rathman³, V. Ribeiro³, M. Vinken⁴, and C. Yang^{2,3
  1}Liverpool John Moores University, Liverpool, United Kingdom; ²MN-AM GmbH, Nuremberg, Germany; ³MN-AM LLC, Columbus, OH; and ⁴Vrije Universiteit Brussel, Brussels, Belgium
  Poster Board P295, Abstract 2557
  Monday, March 22, 2021
  Registered attendees of SOT 2021 can access this presentation at the SOT 2021 Virtual Event pages
• A Case Study to Leverage Public and Commercial Resources to Improve In Silico Chemical Safety Assessment
  A. Mostrag-Szlichtyng¹, K. Arvidson², M. Cronin³, D. Ebbrell³, S. Enoch³, J. Firman³, J. Madden³, J. Marusczyk⁴, P. Volarath², J. Rathman¹, C. Schwab⁴, and C. Yang^{1,4
  1}MN-AM, Columbus, OH, USA, ²US FDA/CFSAN, College Park, MD, USA ³Liverpool John Moores University, Liverpool, UK, and ⁴MN-AM, Nuremberg, Germany
  Poster Board P220, Abstract 2754
  Tuesday, March 23, 2021
• Estimating EC3 (Effective Concentration for a Stimulation Index of Three) Confidence Bounds and Uncertainties for Skin Sensitization Based on Structure Similarity and Assay Profiles
  J. Rathman¹, C. Yang^1,2, M. Cronin³, and S. Enoch^{3
  1}MN-AM, Columbus, OH, USA ²MN-AM, Nuremberg, Germany, and ³Liverpool John Moores University, Liverpool, UK
  Poster Board P264, Abstract 2798
  Tuesday, March 23, 2021
• New Public CSRML-Based Structure-Fingerprint Method for Profiling and Categorizing PFAS Structures for Modeling and Read-Across
  A.M. Richard¹, R. Lougee², G. Patlewicz¹, C. Grulke¹, A. Williams¹, C. Yang³, J. Rathman⁴, and T. Magdziarz^{3
  1}US EPA, Research Triangle Park, NC, USA, ²Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA, ³MN-AM, Nuremberg, Germany, and ⁴MN-AM, Columbus, OH, USA
  Poster Board P303, Abstract 2565
  Monday, March 22, 2021
  Registered attendees of SOT 2021 can access this presentation at the SOT 2021 Virtual Event pages

Oral Presentations

• A New Paradigm in Threshold of Toxicological Concern Transforming Cramer Class Approaches to Chemotype Grouping Based on Chemoinformatics Analysis of a Highly Curated Database
  Chihae Yang
  MN-AM, Nuremberg, Germany and Columbus, OH, USA
  Workshop Session 1234
  Monday, March 22, 2021
  Registered attendees of SOT 2021 can access this presentation at the SOT 2021 Virtual Event pages
• The New Cancer Potency (Updated CPDB) Database for TTC
  M.T. Cronin¹, J.W. Firman¹, J. Liu², A. Mostrag-Szlichtyng², K.R. Przybylak¹, and A. Tarkhov^{3
  1}Liverpool John Moores University, Liverpool, UK, ²Altamira LLC, Columbus, OH, USA, and ³Molecular Networks GmbH, Nuremberg, Germany
  Workshop Session 1232
  Monday, March 22, 2021
  Registered attendees of SOT 2021 can access this presentation at the SOT 2021 Virtual Event pages

Special Events

• MN-AM, Molecular Networks & Altamira: Novel Chemoinformatics Platform ChemTunes·ToxGPS^® and Its Public Version COSMOS Next Generation
  MN-AM (Molecular Networks & Altamira) presents an innovative chemoinformatics approach to estimate NOAEL confidence bounds for a target based on experimental NOAEL of compounds selected based on mode-of-action categories and analog quality (structure- and property-based similarity). The new COSMOS Next Generation public data and knowledgebase system will also be presented in this session.
  Tuesday, March 23, 2021
  Download invitation